Alterations of eye movements in Parkinson's disease with high frequency subthalamic nucleus deep brain stimulation

Objectives: High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has shown to be highly effective in reducing levodopa sensitive parkinsonian motor symptoms. Furthermore recent studies suggest that the STN is also involved in the control of eye movements. However, an affectation of frontobasal non dopaminergic pathways is considered to be responsible for some aspects of oculomotor dysfunction in IPD as well. We wondered if a registration of eye movement via videooculography (VOG) in DBS patients in the “on“ and “off“ state could elicit a more precise classification of eye movement changes…