Performance of different MRI based parameter maps to assess penumbral flow in stroke: a 15O-water PET study

Background: The accuracy of perfusion weighted magnet resonance imaging (PW-MRI) based quantitative maps of cerebral blood flow (CBF-MRI), cerebral blood volume (CBV-MRI), mean transit time (MTT-MRI) and relative maps of time to peak (rTTP-MRI) remains a matter of debate. We validated CBF-, CBV-, MTT- and rTTP-PWI on quantitative CBF measurement by 15O-water positron emission tomography (CBF-PET) with respect to penumbral flow (