Constituents of Acmella ciliata (H.B.K.) Cass

Acmella ciliata (H.B.K.) Cass. is a herbaceous Asteraceae native to tropical South America. Traditionally, the plant is used as a spice and against toothache due to its anaesthetic and pungent taste. In Germany, an extract of the plant is marketed as active ingredient of the phytomedicine Spolera® which is used against e.g. sprains and contusions. Previous phytochemical investigation of A. ciliata led to the isolation of spilanthol and several related carboxylic acid amides [1] as well as the detection of four flavonoid glycosides [2], whereas no information exists about the occurrence of further classes of phyt…