Laser induced thermal ablation of colorecttal cancer metastases to liver causes a significant tumor specific activation of lymphocytes

Local ablation is an extensively used treatment of inoperable solid liver tumors. We could recently show a clear immuno modulatory side effect with a significant activation of tumor specific T cells after radiofrequency ablation in a VX2 liver tumor model in rabbits and in patients suffering from hcc and colorectal cancer metastases to the liver. This study provide that these putative side effects of ablation of solid malignancy in the liver can be also found after LiTT of colorectal cancer metastases to the liver. Materials and methods: 11 patients with liver metastases of colorectal cancer underwent LITT. Bloo…