Polymorphisms in RIG-I like helicases and their influence on the course of Hepatitis C Virus infection
F Hoffmann, A Schmidt, J Hellmuth, T Müller, N Reisch, J Glas, M Folwacny, S Endres, S Rothenfusser · Zeitschrift für Gastroenterologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Hepatitis C is a major cause of liver cirrhosis, liver failure and hepatocellular carcinoma in humans. Hepatitis C Virus (HCV) infects about 3% of the human population. Interestingly the course of infection varies widely among patients. Approximately 15–20% of the infected individuals clear the infection spontaneously, whereas in 80% the infection presides in a chronic state. Virus-related factors and clinical risk factors of the host such as sex, alcohol consumption and age at infection do not allow to predict the development of a chronic status. It is therefore suspected that the susceptibility to chronic HCV…
