CareLit Fachartikel

WISP1: A novel regulator of idiopathic pulmonary fibrosis amenable to therapeutic intervention

M Königshoff, A Jahn, K Kitowska, O Amarie, F Rose, L Fink, W Seeger, A Guenther, O Eickelberg · Pneumologie · 2008 · Heft 01

Dokument
917227
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Königshoff, A Jahn, K Kitowska, O Amarie, F Rose, L Fink, W Seeger, A Guenther, O Eickelberg
Ausgabe
Heft 01 / 2008
Seiten
–
Erschienen: 2008-01-07 00:00:00
ISSN
0934-8387
DOI
10.1055/s-2007-1032272

Zusammenfassung

Idiopathic pulmonary fibrosis (IPF) is a devastating disease, characterized by severe loss of respiratory function due to enhanced extracellular matrix (ECM) deposition and (myo)fibroblast proliferation. Repetitive epithelial injuries with impaired alveolar wound healing represent a trigger mechanism for development of fibrosis, but molecular mechanisms linking alveolar epithelial cell (AEC) repair with development of fibrosis are poorly understood. Using whole genome microarrays, we report altered gene expression profiles of AEC derived from mice with lung fibrosis. In particular, we demonstrate that WISP1 (CCN…

Schlagworte

Pneumologie