Phosphodiesterase 2 Inhibition diminished acute lung injury IN murine Pneumococcal Pneumonia
M Witzenrath, B Gutbier, B Schmeck, H Tenor, J Seybold, R Kuelzer, G Grentzmann, A Hatzelmann, TJ Mitchell, C Schudt, S Rosseau, N Suttorp, H Schütte · Pneumologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Rationale: Severe pneumococcal pneumonia frequently causes respiratory failure. Both pathogen factors and an uncontrolled host response may contribute to acute lung injury (ALI) by impairing microvascular barrier function. Objectives: To analyze phosphodiesterase 2 (PDE2) as a potential target in pneumonia-induced lung microvascular hyperpermeability. Methods: HUVECs and isolated mouse lungs were challenged with the pneumococcal exotoxin pneumolysin in the presence or absence of the selective PDE2 inhibitors PDP or PDP-2. Transcellular electrical resistance or human serum albumin (HSA) leakage in bronchoalveolar…
