Telomere shortening and p21-checkpoint inactivation characterize multistep hepatocarcinogenesis in humans
RR Plentz, A Lechel, YN Park, H Kim, F Nellessen, BHE Langkopf, L Wilkens, MP Manns, A Destro, B Fiamengo, M Roncalli, KL Rudolph · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Telomere shortening and DNA-damage-checkpoint inactivation have been identified as molecular hallmarks characterizing early carcinogenesis in humans but it is unknown, whether these molecular features coincide at specific stages of multistep carcinogenesis in humans. The preneoplasia-carcinoma sequence of human hepatocellular carcinoma (HCC) is not well defined. Small cell changes (SCC) and large cell changes (LCC) are possible precursor lesions. The molecular characterization of these potential precursor lesions could help to define multistep hepatocarcinogenesis in humans. We analyzed hepatocellular telomere l…
