Increased IRF–1 gene expression in A allele carriers of the G–300A promoter polymorphism

Aim: Interferon regulatory factor–1 (IRF–1) is a type I and type II interferon (IFN) inducible transcription factor which is involved in the transcriptional regulation of the IFN response. By applying in vitro assays, a single nucleotide polymorphism (SNP) at position –300 within the promoter region of the IRF–1 gene has been demonstrated to influence its transcriptional activity. Recently, we were able to report on an association of the G–300A IRF–1 genotype and the outcome of an HCV infection. Our present study aimed to investigate whether IRF–1 gene expression is related to G–300A IRF–1 genotype in healthy in…