Elevated plasma nociceptin (N/OFQ) level and alteration of brain N/OFQ system in experimentally induced cholestasis in bile duct ligated (bdl) rats
T Csák, M Hantos, A Horváth, A Folhoffer, J Osztovits, Z Visnyei, A Zalatnay, P Nagy, K Tekes, F Szalay · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Nociceptin (N/OFQ) is an endogenous agonist of an opioid-receptor-like receptor. Elevated plasma N/OFQ level has been described in primary biliary cirrhosis (PBC). Opioid-antagonists alleviate the cholestasis associated-itching in PBC indicating the opioids' role in pruritus. N/OFQ-induced itching in mice has been published. Aim: To investigate N/OFQ-levels in plasma, liver, and brain tissue in experimentally-induced cholestasis. Methods: Cholestasis was induced by common-bile-duct ligation in 14 F344 rats. Twelve sham-operated animals served as control. Animals were sacrificed on 14th postoperative day by…
