mRNA expression of selenoproteins in human colonic mucosa cells
J Molnár, B Molnár, O Galamb, A Németh, T Zágoni, P Miheller, B Galamb, Z Tulassay · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Selenium (Se) is an essential trace element. A significant inverse correlation between the incidence of gastrointestinal cancer and serum Se concentrations was observed in epidemiological and prospective human studies. The exact mechanism for Se as an anti-carcinogenic element is not known. Glutathione peroxidases (GPX) and other selenoenzymes have been reported to play a pivotal role. Material and methods: The expression of GPX 1, 2, 3, and 4 mRNA, selenoprotein P and selenoprotein W mRNA was measured in human normal colonic mucosa cells (n=8), in human colonic adenoma cells without dysplasia (n=6…
