Peripheral mononuclear TNF-α, visfatin, and resistin mRNA expression in overweight women with type 2 diabetes

Background and Aims: Adipocytokines, like TNF-α, visfatin and resistin, have been suggested to be important regulators of insulin resistance, and may provide the molecular links between visceral obesity, type 2 diabetes and atherosclerosis. We examined whether TNF-α, visfatin and resistin mRNA expression from human peripheral mononuclear cells is altered in type 2 diabetes and whether it is related to indices of obesity and insulin resistance. Materials and Methods: We studied 16 overweight women (BMI>26) with type 2 diabetes (DM2) and 26 healthy women with normal glucose tolerance (14 with BMI>26 (NGT-overw), a…