Elevated CSF free kappa light chains support the diagnosis of multiple sclerosis

Background: Several studies have demonstrated kappa free light chains (KFLCs) in CSF of MS-patients but so far only small cohorts have been examined and mainly KFLCs were simply qualitatively detected. However, using a recently developed particule immunoassay protocol (FreeliteTM, The Binding Site, UK) it has become possible to make rapid and automated quantitative measurements of KFLCs using nephelometry. Methods: Between 2001 and 2006 we collected CSF and serum samples from 438 unselected patients including a group of 70 MS-patients (41 definite MS, 29 possible MS). Fluids were analysed using nephelometry and…