TGF-beta and hepatocyte transdifferentiation in liver fibrogenesis
S Dooley, L Ciuclan, P Godoy, S Kanzler, R Heuchel, E Ueberham, R Gebhardt, J Hamzavi, P Mertens, K Breitkopf · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Chronic liver intoxication results in overrepresentation of TGF-β in the liver, which induces activation of hepatic stellate cells, deposition of extracellular matrix and hepatocyte (HC) apoptosis. Since TGF-β signal transduction and its biological responses are highly complex, we endeavored a Systems Biology approach to understand the diverse observations for TGF-β and Smads in liver cells. Apoptosis assays revealed that TGF-β dependent apoptosis is only an inferior function of this cytokine on hepatocytes. Using a top down approach by Affymetrix array gene expression profiling in mouse HC stimulated with 5ng/m…
