Interleukin-26 enhances proinflammatory gene expression and its expression is increased in intestinal inflammation in vivo
J Dambacher, F Beigel, A Kaul, K Zitzmann, D Haller, B Göke, H Diepolder, R Bartenschlager, C Auernhammer, S Brand · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background/aims: The role of IL-26, a novel IL-10 like cytokine expressed in activated human Th1 cells without murine homolog, in human disease is completely unknown. Therefore, the aim of this study was to analyze its role in intestinal and hepatic inflammation and viral infection. Methods: Expression studies were performed by RT-PCR. Signal transduction was analyzed by Western blot experiments and ELISA. Cell proliferation was measured by MTS assay. Results: All examined IEC lines and the hepatic cell lines Huh-7, Hep3B and primary hepatocytes express both IL-26 receptor subunits IL-20R1 and IL-10R2. IL-26 act…
