Dynamic sonographic tissue perfusion measurement to evaluate renal cortical perfusion in healthy and insufficient kidneys

Objective: To prevent loss of renal function it is necessary to find very early noninvasive functional criteria of impending irreversible tissue damage. We used therefore the novel method of dynamic tissue perfusion measurement to prove its ability of monitoring a creeeping, subliminal loss of renal microvasculature. Method: Renal cortical perfusion was measured under strictly standardized conditions in millimeter-thin slices with a specially designed software for dynamic (i.e. heart cycle synchronized) perfusion measurement: PixelFlux (www.chameleon-software.de) in 102 healthy probands (0,4–18, mean 6 years) an…