CareLit Fachartikel
Transcriptional Targeting of Activated Hepatic Stellate Cells by Modular Promoter Fragments
M Friedrich, AM Gressner, R Weiskirchen, J Herrmann · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
919063
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Jahr
2008
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Zusammenfassung
Transdifferentiation of hepatic stellate cells (HSC) into myofibroblast-like cells is a key event in liver fibrogenesis accompanied by differential gene regulation. Antifibrotic strategies focus on manipulation of this relevant cell type, e.g. induction of HSC apoptosis, but to date a specific and easy-to-handle targeting of activated HSC is not reported. As demonstrated by Lemken et al. [1] a targeting of reporter genes to liver using enhancer elements of hepatocyte specific genes fused to a minimal promoter was successful. Therefore, we proofed if short promoter fragments with essential cis-acting regulatory e…
Schlagworte
Fibrosis
Gene Therapy
HSC
Promoter
Targeting
Zeitschrift für Gastroenterologie
