Identification of Fibroblast Growth Factor Receptor 2IIIb (FGFR2IIIb) as tumor suppressor in hepatocellular carcinoma
T Amann, F Bataille, T Spruss, P Wild, C Liedtke, M Mühlbauer, P Kiefer, C Trautwein, A Bosserhoff, C Hellerbrand · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Fibroblast growth factor receptor 2 isoform b (FGFR2IIIb) is highly expressed in hepatocytes and has been shown to play an important role in liver homeostasis and regeneration. Here, we analyzed the expression and function of FGFR2IIIb in hepatocellular carcinoma (HCC). Methods: FGFR2IIIb expression was analyzed by quantitative PCR and western blotting. Further, immunohistochemical analysis of a tissue microarray containing HCC and corresponding non-cancerous liver tissue of 85 patients was performed. Results: In HCC tissues and cell lines FGFR2IIIb expression was lower than in primary human hepatocytes and corr…
