MDM4 and eEF1A2, new oncogene candidates in human HCC, revealed by high-resolution array-bases CGH

Although the etiology of HCC is well characterized (e.g. HBV, HCV, alcohol, and NASH), the host molecular alterations preceding HCC development are less well understood. In order to identify novel host driver genes of human hepatocarcinogenesis, we performed a combination of high-resolution fine-mapping of genomic imbalances using array-based CGH (aCGH) with extensive expression and functional analyses. Using aCGH (n=63) we identified 36 common loci exhibiting small amplifications or putative homozygous deletions. Among them, we detected a novel single amplicon at 1q32.1 that contained the p53-regulating oncogen…