Impaired liver regeneration after subtotal 90% hepatectomy is associated with suppression of NF-B activation and proregenerative genes

Introduction: A main concern regarding extended hepatectomies (i.e. in tumor resections or in living donor liver transplantation [LDLT]) is that the small remnant liver may lead to liver failure or death of patient or donor. Therefore, we investigated the molecular events after subtotal hepatectomy in a rat model. Methods: Male Wistar rats were subjected to a 70% or 90% partial liver resection. The regenerating liver was explanted at different time points after operation. Sham operated animals served as controls. Clinical and laboratory parameters (liver-body-weight ratio and liver function tests) were assessed…