Mono-Center Study: Acetaminophen-Induced Liver Injury is the most Common Cause of Acute Liver Failure

Aims: Acetaminophen-Induced hepatotoxcity is likely the most important cause of acute liver failure (ALF) in the western countries. To date however, no data exists on the relevance of paracetamol intoxication in Germany. AIM: To determine the incidence and risk factors of acetaminophen-induced hepatotoxcity and ALF in our center over a four-year period. Methods: A retrospective mono-center four-year study (2002–2005) enrolled 20 patients [15 females (75%) / five males (25%), at a median of 31±12 years of age] with paracetamol poisoning transferred to our transplant center; only 18 of these fulfilled established…