Electropharmacogram from quercetin is similar to that of moclobemide and other antidepressant drugs

Background Neurotransmitter action in the brain is always accompanied by changes in electrical activity. These are reflected in the electropharmacograms based on quantitative field potential recording in the presence of drugs. Recording from four brain areas and dividing the spectral frequency data into six ranges provides 24 variables for construction of the electropharmacogram (pattern of electrical pre-post changes of drug action). Method Adult rats (>5 month old) were instrumented by four bipolar concentric electrodes connected by a small base plate which was positioned stereotactically for insertion of the…