18F-labelled gentiobiose as potential PET-radiotracer for specific bacterial imaging: precursor synthesis, radiolabelling and in vitro evaluation
Felicitas Landau, Sven Hermann, Sonja Schelhaas, Michael Schäfers, Silke Niemann, Andreas Faust · Nuklearmedizin - NuclearMedicine · 2024 · Heft 05 · S. 300-305
Bibliografische Angaben
Zusammenfassung
Abstract Aim Bacterial infections are a clinical challenge, requiring fast and specific diagnosis to ensure effective treatment. Therefore, this project is dedicated to development of positron emission tomography (PET) radiotracers specifically targeting bacteria. Unlike previously developed bacteria-specific radiotracers, which are successful in detecting Gram-negative bacteria, tracers capable of imaging Gram-positive infections are still lacking. Methods The disaccharide gentiobiose as abundant part of the cell wall of Gram-positive bacteria could fill this gap. Herein, the synthesis and evaluation of 2‘-deox…
