Cyclin E1 is an essential pro-fibrotic factor in the liver

E-Type cyclins E1 (CcnE1) and E2 (CcnE2) are important mediators for driving resting cells into the proliferative state of the cell cycle but are dispensable in continuously dividing cells. We recently showed that CcnE1 is a key player for hepatocyte proliferation during liver regeneration, whereas CcnE2 is essentially a regulator of CcnE1. Liver fibrogenesis is associated with proliferation of hepatocytes and hepatic stellate cells (HSC). Thus, the aim of this study was to investigate the potential contribution of CcnE1 for liver fibrosis in human and mice. Immunohistochemistry of human fibrotic liver sections…