Impaired liver regeneration in GBA2-deficient mice
ER Almajan, R Sandhoff, MC Gonzales, R Büttner, S Weber, F Lammert, T Sauerbruch, Y Yildiz · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Beta-glucosidase 2 (GBA2) deficient mice accumulate the naturally occurring glycolipid glucosylceramide (GlcCer) in different tissues, including the liver. Glycolipids are a class of cellular lipids that differ from the regular membrane phospholipids in a remarkable variation in its head group structures. This suggests that glycolipids serve specialized functions in cell signalling, proliferation differentiation and recognition processes, all involved in liver regeneration. Since significant changes in the glycolipid content and distribution have been reported during rat liver regeneration, the present study was…
