CareLit Fachartikel
Dynamin GTPase activity mediates dedifferentiation of cultured hepatocytes via transcriptional changes
I Ilkavets, S Lukowski, A Bachmann, C Sticht, C Meyer, N Gretz, S Dooley · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
919946
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Drug and metabolite endocytosis, viral and bacterial infections, and transcitosis are facilitated by large GTPase dynamin. However, the underlying molecular mechanisms of dynamin action on homeostasis in hepatocytes without additional external signals (like growth factors, transferrin or drugs) are poorly understood. Therefore, we depleted hepatocytes of functional dynamin by adenoviral overexpression of a GTPase deficient dynamin mutant (DN-dynamin) for 48h and compared genome wide oligonucleotide microarrays, morphology and biochemical functions with AdLacZ infected controls. Blunting dynamin function leads to…
Schlagworte
GTPase
apoptosis
differentiation
dynamin
hepatocytes
microarray
morphology
Zeitschrift für Gastroenterologie
