CareLit Fachartikel

Ischemia-reperfusion injury disrupts architecture of tight junction protein 1 in the common bile duct

SM Brunner, P Rümmele, HJ Schlitt, S Fichtner-Feigl · Zeitschrift für Gastroenterologie · 2010 · Heft 01

Dokument
919952
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
SM Brunner, P Rümmele, HJ Schlitt, S Fichtner-Feigl
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-12 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1246472

Zusammenfassung

Bilary complications remain a major cause of graft failure after liver transplantation. In part, these problems result from ischemia-reperfusion injury. In a healthy status the inside of the common bile duct is covered by a monolayer epithelium. Between biliary epithelial cells tight junctions play an essential role for permeability and barrier function of the bile duct. Tight junction protein 1 (TJP1) is a member of the tight junction family and is normally located at the apical part of the epithelium. TJP1 is connected with occludin, claudins and cytoskeletal filaments and plays a crucial role in organizing th…

Schlagworte

Ischemia-reperfusion injury Liver Transplantation common bile duct tight junction tight junction protein 1 Zeitschrift für Gastroenterologie