Increased bile acid levels reduce antiviral treatment response in genotype 2/3 hepatitis C patients whereas gamma-GT selectively predicts SVR in genotype 1
R Iwata, B Stieger, JC Mertens, O Goetze, IV Martin, K Sabrane, A Vergopoulos, J Braun, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: The likelihood of achieving a SVR to antiviral therapy depends on both viral and host characteristics. Recently, in vitro studies demonstrated that bile acids (BA) upregulate HCV replication and interfere with IFN effects. Aims: To investigate the influence of BA concentrations and a frequent ABCB11 transporter SNP (associated with lower BSEP expression) on viral load and SVR in HCV pts. Methods: N=198 pts with chronic HCV infection from the Swiss HCV Cohort study treated with PEG-IFN/ribavirin were included. 110 Caucasian individuals undergoing liver resection served as controls. The common ABCB11 variant…
