The Heme oxygenase 1 product Biliverdin interferes with HCV replication by increasing anti-viral interferon response
G Sass, E Lehmann, WH El-Tantawy, M Ocker, R Bartenschlager, V Lohmann, S Hashemolhosseini, G Tiegs · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: The anti-apoptotic and hepatoprotective protein heme oxygenase-1 (HO-1) has been shown to interfere with replication of viruses, e.g. hepatitis B virus (HBV) and hepatitis C virus (HCV). Since HO-1 degrades heme to carbon monoxide (CO), iron and biliverdin, we investigated the effect of each product on HCV replication in vitro. Methods: HO-1 was induced using cobalt-protoporphyrin-IX (CoPP). Huh-5–15 cells, stably expressing HVC genes NS3 to NS5B, and LucUbiNeo-ET cells, containing additionally the firefly luciferase gene, were used to monitor HCV replication. Biliverdin was added in neutral…
