Additional pharmacological options in the therapy of generalized epilepsies

Introduction: In generalized epilepsies exists an altered activity of neurotransmitter and neuropeptide concentrations and a disturbance of ion channels in the hippocampus. A completed neuronal network in the hippocampus will be developed, and additional pharmacological options in the antiepileptic therapy will be derived from the neuronal network. Material and Methods: In the hippocampus, dopaminergic neurons which have a high activity transmit a strong postsynaptic excitatory impulse upon glutaminergic neurons via D2 receptors. The glutaminergic neurons in their turn strongly inhibit serotonergic neurons via N…