Multiparametric MRI analysis of patients with amyotrophic lateral sclerosis compared to controls

Introduction: Multiparametric MRI analysis was applied to patients with amyotrophic lateral sclerosis (ALS) in comparison to controls in order to obtain comprehensive information on the affection of cerebral white matter. Material and Methods: Fractional anisotropy mapping from diffusion tensor imaging (DTI) and intensity based analysis of T1-weighted 3-D MRI were applied to data sets of a samples of nineteen ALS patients (9m/10f, 56±12 years) compared to age and gender matched controls. All data analyses were performed in one common analysis software environment (TIFT – Tensor Imaging and Fiber Tracking). Fig.1…