Correlates to the seizure onset zone in interictal EEG/fMRI recordings

Background and Purpose: Recent studies of combined EEG/fMRI in the interictal state report a good concordance of the delineated interictal epileptic network (i.e. the irritative zone) to ictal electroclinical data. We evaluated whether BOLD correlates to interictal epileptic discharges (IEDs), analysed at different threshold criteria, allow a localisation of the seizure onset zone in accordance to semiology, ictal EEG-videotelemetry, structural MRI (sMRI) and postoperative outcome. Methods: Ten patients with drug resistant epilepsy, eight with unilateral mesial temporal sclerosis (MTS) and two with focal cortica…