Right ventricular remodeling in response to pressure overload
H Luitel, A Sydykov, B Kojonazarov, B Egemnazarov, N Weissmann, W Seeger, F Grimminger, R Schermuly, HA Ghofrani · Pneumologie · 2010 · Heft 03
Bibliografische Angaben
Zusammenfassung
Right ventricular hypertrophy (RVH) is an adaptive response to increased hemodynamic load in several types of pulmonary and congenital heart diseases. However, chronic overload may result in right ventricular failure, which further complicates the disease progression. The aim of the study was to investigate the time course of structural and functional changes of the heart in the murine model of pressure overload-induced RVH and clarify the driving molecular mechanisms of the remodeling process. RVH was induced in male C57 B l/6 mice by the pulmonary artery (PAB) by reduction of the vessel diameter to approximate…
