Atherosclerosis, Inflammation and Lipoprotein Glomerulopathy in Kidneys of ApoE-/-/LDL-/- double knockout mice
A Langheinrich, M Kampschulte, F Scheiter, C Dierkes, P Stieger, RM Bohle, W Weidner · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney dysfunction in these mice. Methode: Kidneys from apoE-/-/LDL-/- double knockout mice at the age of 80 weeks (n=6) and C57/BL control mice (n=5) were infused with Microfil, harvested and scanned with micro-CT (12µm cubic voxels) and Nano-CT (900 nm cubic voxels). We quantitated the total vascular volume using micro-CT. Number and area (µm2) of glomeruli was measured using histology. Ergebnis: At the age o…