Association of T cell reactivity with diapep277 interventional treatement in newly diagnosed paediatric and adult type 1 diabetes patients

Objective: DiaPep277 peptide is derived from heat shock protein (hsp)60. We aimed to investigate how T-cell reactivity relates to interventional DiaPep277 treatment in type 1 diabetes (T1D). Research design and methods: 50 adults and 49 children with recent onset T1D were investigated in the p520/521 DiaPep277 intervention study. Secretion of IFN-γ, IL-5, IL-13 and IL-10 by PBMC upon stimulation with autoantigens GAD65, hsp60, two IA2 peptides was determined applying ELISPOT. Antigen-reactive responses were expressed as Stimulation index (SI). Regression analysis was adjusted for sex, age, BMI, DiaPep277 treatme…