Comparison of T-cell interferon gamma release assays with the tuberculin skin test for the diagnosis of latent tuberculosis infection in HIV-seropositive individuals from a countr…

Background: Infection with the human-immunodeficiency-virus (HIV) is the greatest risk factor for the development of tuberculosis in Africa. We ascertained the performance of novel T-cell interferon-gamma release assays (TIGRA) for the diagnosis of latent tuberculosis infection (LTBI) in patients with HIV-infection in an area of TB endemicity. Methods: Tuberculin skin test, Quantiferon Gold in tube and T-Spot.TB assays were performed on the peripheral blood of newly diagnosed HIV+ individuals without signs and symptoms of active tuberculosis at an outpatient clinic at Makerere University in Kampala, Uganda. Resu…