Alveolar Remodeling in a Mouse Model of Chronic Tobacco Smoke Inhalation
N Parajuli, M Seimetz, M Roth, B Fuchs, R Schermuly, H Ghofrani, C Schudt, C Hesslinger, W Seeger, F Grimminger, N Weissmann · Pneumologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: COPD is a progressive disease having non-fully reversible airflow limitation associated with chronic obstructive bronchitis and emphysema. Genetic factors, environmental pollution and tobacco smoke inhalation are the major factors for induction of this disease. To identify pathogenetic mechanisms of lung emphysema development, the aim of this study was to establish a mouse model of tobacco-smoke induced COPD. Material and Methods: Wild type mice (C57/Bl6J) were exposed to cigarette smoke for 6 hours/day, 5 days per week up to 8 months. Exposure of smoke was maintained with a particle concentration…
