CareLit Fachartikel
Specific inhibition of NF-κB subunits prevents norepinephrine dependent, athero-thrombotic gene expression in experimental models of psychosocial stress
Z Djuric, PM Humpert, PP Nawroth, A Bierhaus · Diabetologie und Stoffwechsel · 2008 · Heft 04
Dokument
921117
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Aims: Disease-related psychosocial stress is common in patients with diabetes. Stress evoked elevated catecholamine levels have been shown to induce the redox-sensitive, proinflammatory transcription factor NF-κB, which is supposed to contribute to the pathogenesis of the micro and macrovascular late diabetic complications. Since most of the NF-κB inducers also trigger the release of radical oxygen species, antioxidants were supposed to effectively block NF-κB activation. Although certain studies have indicated beneficial effects of NF-κB inhibition, numerous recent reports have shown that long-term systemic inh…
Schlagworte
Defense Mechanisms
Chromatin Immunoprecipitation
Atherosclerosis
Catecholamine
Antioxidants
Chromatin
Lead
Diabetologie und Stoffwechsel
