Effect of PPI therapy on lower esophageal sphincter in hypertensiv LES

Background: Hyperreactive lower esophageal sphincter is a rare motility disorder of the LES. Nissen fundoplication was shown to be effective in the treatment of patients with GERD induced hypertensive LES. Aim of this study was to determine the efficacy of PPI therapy in patients with hypertensive LES. Patients and methods: 10 consecutive patients (2 males, 8 females, median age: 58 years) was enrolled in the study. Hypertensive lower esophageal sphincter was detected by eight channel, water perfused esophageal manometry system. Definition of hypertensive LES: average pressue of lower esophageal sphincter is hig…