Infection as a possible etiological factor of preterm delivery: Place of a proinflamatory cytokines

Aims: Bacterial infection plays important role in pathogenesis of preterm deliveries. Bacterial invasion of choriodecidual space activates the decidua and fetal memberane to produce cytokines including IL–1, IL–6, IL–8, interferon–γ.These proinflammatory cytokines may induce the synthesis and release of prostaglandins that stimulate uterine contractions. Aim: To investigate the possibility of application of proinflammatory cytokine IL–8, and interferon –γ as biochemical markers of local infections in patients with clinical symptoms of preterm delivery. Material and methoods: Investigation comprised 74 pregnant w…