Immune responsiveness in newborns with risk of developing type 1 diabetes
I Spalova, K Flajsmanova, D Bartaskova, P Pithova, Z Hladikova, M Cerna, K Stechova · Ultraschall in der Medizin - European Journal of Ultrasound · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Incidence of type 1 diabetes (T1D) is increasing worldwide. A high increase of T1D incidence is observed in pre-school age children. There is still no potent tool to recognise early signs of cellular autoreactivity which leads to beta cell damage and development of T1D. The naive immune system of the newborn (not yet influenced by external factors) can be used as an important model for studies of the pathogenesis of T1D. Aim: To study the response of cord blood mononuclear cells to diabetogenic autoantigens and infection stimulation in babies with inceased risk of developing T1D. Methods: Cord blood sample…
