Maternal serum ADAM12 levels in IVF pregnancies correlates with PAPP-A, but not with fP-hCG levels during the first trimester
M Ryynanen, H Cuckle, Y Valinen, P Laitinen, L Morin-Papunen · Ultraschall in der Medizin - European Journal of Ultrasound · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background. We wished to investigate the correlation between IVF and Down's syndrome screening analytes, especially ADAM12 and PAPP-A and fβ-hCG during the first trimester. Material and Methods. Retrospective analysis. ADAM12 and PAPP-A and fβ-hCG was measured on 142 consecutive singleton IVF pregnancies and compared with 186 naturally occurring singleton pregnancies during the first trimester. Results. We derived MoM's and weight correction equations for all three analytes from the subjects and controls. The median values were: ADAM12=1.165 MoM, PAPP-A=0.732 MoM, and fβ-hCG=0.902 MoM. Based on the log SDs (0.21…