IP-10 predicts HCV clearance, relapse or nonresponse in HIV-HCV-coinfection
T Reiberger, JH Aberle, M Kundi, A Rieger, A Gangl, H Holzmann, M Peck-Radosavljevic · Zeitschrift für Gastroenterologie · 2008 · Heft 06
Bibliografische Angaben
Zusammenfassung
Introduction: Interferon gamma inducible protein 10 (IP-10) is elevated in hepatitis C virus (HCV) mono-infection, correlates with hepatic inflammation and predicts nonresponse (NR) to antiviral therapy. We aimed to clarify the pathogenetic role and the predictive value of IP-10 in HCV-HIV-coinfection. Methods: IP-10 levels of 30 HIV-HCV-coinfected patients undergoing 48 weeks of antiviral therapy with pegylated-interferon-! 2a (180“g/week) and ribavirin (800–1200mg/day) were measured at baseline and 24 hours after first IFN dose. Associations between IP-10 and histological findings, hepato-venous pressure gradi…
