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Glitazone-mediated vascular protection requires high mobility group A1 protein – a new PPARgamma coregulator

M Bloch, A Prock, F Paonessa, A Foryst-Ludwig, K Kappert, J Spranger, T Unger, A Fusco, D Sedding, A Brunetti, U Kintscher · Diabetologie und Stoffwechsel · 2010 · Heft 04

Dokument
921671
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Jahr
2010
Publikation
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
M Bloch, A Prock, F Paonessa, A Foryst-Ludwig, K Kappert, J Spranger, T Unger, A Fusco, D Sedding, A Brunetti, U Kintscher
Ausgabe
Heft 04 / 2010
Seiten
–
Erschienen: 2010-04-21 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0030-1254012

Zusammenfassung

Previously we have shown that the chromatin-modifying high mobility group A1 protein (HMGA1) is required for Peroxisome Proliferator-activated Receptor gamma (PPARgamma)-mediated transrepression in vascular smooth muscle cells (VSMCs). The aim of the present study was to characterize the in-vivo relevance of HMGA1 in PPARgamma-mediated beneficial effects after vascular injury. The effect of pioglitazone (pio) treatment in wildtype (wt) and HMGA1-deficient mice on neointima formation was investigated in a mouse femoral artery after wire-induced injury. Arterial injury resulted in a prominent formation of a neoint…

Schlagworte

Diabetologie und Stoffwechsel