Clinical and molecular characterization of therapy-related myeloid neoplasms after treatment for childhood acute lymphoblastic leukemia

Therapy-related malignant myeloid neoplasms (t-AML/t-MDS) are a devastating late effect of treatment for childhood acute lymphoblastic leukemia (ALL). To gain insights into the etiology of t-AML/t-MDS, we performed a systematic three-step analysis: step 1) We identified all patients from the ALL-BFM database, being registered with a t-AML/t-MDS as an event; step 2) Based on the availability of biological specimens and completeness of clinical data, we established a cohort representing the incident population of t-AML and t-MDS for a 10 year interval (1996–2005); step 3) for a subset of this incident cohort, high…