CareLit Fachartikel

Plk1 is a novel target for high-risk neuroblastoma therapy

F Goeser, S Ackermann, J Schulte, V Ehemann, A Eggert, B Hero, F Berthold, M Fischer · Klinische Pädiatrie · 2010 · Heft 05

Dokument
921696
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
F Goeser, S Ackermann, J Schulte, V Ehemann, A Eggert, B Hero, F Berthold, M Fischer
Ausgabe
Heft 05 / 2010
Seiten
–
Erschienen: 2010-05-07 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0030-1254472

Zusammenfassung

Aims: To determine Plk1 as a potential target for neuroblastoma therapy. Methods: PLK1 transcript levels of 476 neuroblastomas were correlated with prognostic markers and outcome. Seven neuroblastoma cell lines were treated with various concentrations of BI 2536 and changes in cell proliferation and cell cycle distribution were determined. Nude mice with IMR-32 neuroblastoma xenografts were treated with BI 2536. Results: PLK1 up-regulation is associated with unfavorable markers such as stage 4, age >18 months and MYCN amplification (p

Schlagworte

Klinische Pädiatrie