Genetic risk factors for obesity (MAF MC4R and FTO-polymorphisms) in a large cohort of German VLBW infants
S Haller, C Gebauer, H Küster, N Teig, D Müller, H Segerer, W Nikischin, B Roth, T Höhn, A von der Wense, E Kattner, J Möller, M Vochem, C Wieg, C Härtel, E Herting, W Göpel · Klinische Pädiatrie · 2010 · Heft 06
Bibliografische Angaben
Zusammenfassung
Aims: Variants in MAF, MC4R and FTO have repeatedly been associated with obesity and partly with Type II diabetes. Small for gestational age infants have an increased risk to become obese and to develop a metabolic syndrome. We hypothesised that these variants could be associated with lower birth weight and with neonatal catch-up-growth thereby causing the association with obesity and Type II diabetes in adults. We tested these variants for association with preterm birth as well as birth weight and weight gain in German very low birth weight (VLBW) infants. Methods: We conducted a prospective multicenter cohort…
