Common Vitamin D Receptor (NR 1I1) gene polymorphisms influence fibrosis progression in chronic hepatitis C patients
JC Mertens, K Baur, J Schmitt, R Iwata, B Stieger, P Frei, J Braun, F Stickel, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and Aims: Chronic hepatitis C (HCV) infection represents a leading cause of end-stage liver disease. Genetic factors modulating fibrogenesis are an emerging explanation for the heterogeneous prognosis. Besides functional implications in calcium homeostasis and osteoporosis, alterations in the VDR pathway have been described as important event in hepatic disorders such as primary biliary cirrhosis and autoimmune hepatitis. Recent studies confirmed anti-inflammatory and antifibrotic effects of VDR-signalling in stellate cells. Reduced VDR signalling due to VDR-gene polymorphisms may lead to increased he…
