Serum lipids in European chronic HCV genotype 1 patients during and after treatment with pegylated interferon-alfa-2a and ribavirin
CM Lange, M von Wagner, J Bojunga, T Berg, H Farnik, A Hassler, C Sarrazin, E Herrmann, S Zeuzem · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Chronic hepatitis C alters the host's lipid metabolism and HCV eradication may be followed by an increase of serum cholesterol to adverse levels. We therefore aimed to determine the impact of chronic hepatitis C and its treatment on circulating lipids in a large European cohort of HCV genotype 1 patients. Methods: The serum lipid profile of 575 HCV genotype 1-infected patients was characterized before, during and after treatment with pegylated interferon-alfa-2a (180 ug/week) plus ribavirin (1000–1200mg/d) for 48 weeks within a randomized controlled clinical trial. Results: Total baseline cholesterol level…
