Multiple new genetic loci associated with kidney function and Chronic Kidney Disease: The CKDGen Consortium
A Köttgen, C Pattaro, C Böger, C Fuchsberger, M Olden, N Glazer, A Parsa, X Gao, Q Yang, M Chen, A Teumer, D Chasman, L Kao, I Heid, C Fox · Das Gesundheitswesen · 2010 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction and Aims: Chronic kidney disease (CKD) is a significant public health problem of increasing prevalence. Previous studies support a genetic contribution to CKD. We therefore aimed to identify genetic risk variants for CKD and reduced estimated glomerular filtration rate (eGFR) using genome-wide association studies in the CKDGen Consortium. Methods: Data from 67,093 Caucasian participants of 20 population-based studies (AGES, Amish, ARIC, ASPS, BLSA, CHS, ERF, FamHS, FHS, KORA, Korcula, Micros, Orcades, NSPHS, RS, SHIP, Vis, and WGHS Studies) were included. We performed meta-analysis of genome-wide as…
